11-Hydroxycannabinol

11-Hydroxycannabinol (also known as 11-OH-THC or 11-hydroxy-THC) is an active metabolite of THC, the primary psychoactive compound found in cannabis. It is created in the body after cannabis is consumed, specifically when THC is metabolized by the liver.

Metabolism

When cannabis is ingested, the body metabolizes THC into 11-Hydroxycannabinol. This process is primarily carried out in the liver by the Cytochrome P450 enzyme system, specifically the enzymes CYP2C9 and CYP3A4. The metabolite is then further metabolized into 11-nor-9-carboxy-THC, a non-psychoactive compound that is the primary metabolite tested for in cannabis drug testing.

Pharmacology

11-Hydroxycannabinol is more potent than THC and crosses the blood-brain barrier more easily. This results in an intensified psychoactive effect when cannabis is consumed orally, as opposed to smoked or vaporized. The compound binds to the cannabinoid receptors in the brain, specifically the CB1 receptor, leading to the psychoactive effects associated with cannabis use.

Medical Use

While the medical use of 11-Hydroxycannabinol is not as extensively researched as THC, it is believed to have similar therapeutic benefits. These may include pain relief, anti-nausea, appetite stimulation, and anti-inflammatory properties. However, more research is needed to fully understand the medical potential of this compound.

See Also

• Cannabinoid
• Cannabis (drug)
• Tetrahydrocannabinol
• Endocannabinoid system