12-Hydroxyheptadecatrienoic acid

From WikiMD's Food, Medicine & Wellness Encyclopedia

12-Hydroxyheptadecatrienoic acid

12-Hydroxyheptadecatrienoic acid (12-HHT) is a lipid molecule that is derived from the metabolism of arachidonic acid in the body. It is a member of the hydroxyeicosatetraenoic acid (HETE) family of lipids and is primarily produced by the cyclooxygenase (COX) enzymes.

Biosynthesis[edit | edit source]

12-HHT is synthesized from arachidonic acid by the action of the COX enzymes, specifically COX-1 and COX-2. These enzymes convert arachidonic acid to prostaglandin H2 (PGH2), which is then further metabolized to 12-HHT by the action of thromboxane synthase.

Biological Role[edit | edit source]

The biological role of 12-HHT is not fully understood. However, it is known to have some activity in the immune system, where it can act as a chemotactic agent for neutrophils. It is also thought to play a role in the regulation of blood pressure and platelet aggregation.

Clinical Significance[edit | edit source]

Elevated levels of 12-HHT have been found in patients with inflammatory diseases such as rheumatoid arthritis and asthma. It has also been implicated in the development of cardiovascular disease, as it can promote the formation of atherosclerotic plaques.

Research[edit | edit source]

Research into 12-HHT is ongoing, with studies investigating its role in various diseases and its potential as a therapeutic target. For example, inhibitors of the COX enzymes, which reduce the production of 12-HHT, are commonly used in the treatment of inflammatory diseases.

This lipid-related article is a stub.


Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD