17α-alkylated anabolic steroid

From WikiMD's Food, Medicine & Wellness Encyclopedia

17α-alkylated anabolic steroids are a class of anabolic steroids that have been chemically modified at the 17th carbon position. This modification allows the steroid to survive first-pass metabolism in the liver, thereby increasing its bioavailability and potency.

History[edit | edit source]

The first 17α-alkylated anabolic steroid, Methyltestosterone, was synthesized in 1935. Since then, many other 17α-alkylated anabolic steroids have been developed, including Oxandrolone, Stanozolol, and Methandrostenolone.

Pharmacology[edit | edit source]

17α-alkylated anabolic steroids work by binding to the androgen receptor, which is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone. Once activated, the androgen receptor stimulates the transcription of specific genes, leading to increased protein synthesis and muscle growth.

Side Effects[edit | edit source]

The use of 17α-alkylated anabolic steroids is associated with several side effects, including liver damage, cardiovascular disease, and changes in mood and behavior. These side effects are due to the steroids' high bioavailability, which allows them to exert strong effects on the body.

Legal Status[edit | edit source]

In many countries, including the United States, 17α-alkylated anabolic steroids are classified as controlled substances, making their non-medical use illegal. However, they are still widely used in bodybuilding and other sports due to their potent muscle-building effects.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD