17-AAG
17-AAG
17-AAG (17-Allylamino-17-demethoxygeldanamycin) is a derivative of the antibiotic geldanamycin, which is an inhibitor of heat shock protein 90 (Hsp90). It is primarily studied for its potential use in cancer treatment due to its ability to interfere with the function of Hsp90, a protein that stabilizes several proteins required for tumor growth.
Mechanism of Action[edit | edit source]
17-AAG binds to the ATP-binding pocket of Hsp90, inhibiting its activity. This inhibition leads to the degradation of client proteins that are essential for the growth and survival of cancer cells. By disrupting the function of Hsp90, 17-AAG can induce the degradation of oncogenic proteins such as HER2/neu, BCR-ABL, and mutant p53, leading to the inhibition of cancer cell proliferation and induction of apoptosis.
Clinical Development[edit | edit source]
17-AAG has been evaluated in several clinical trials for its efficacy in treating various types of cancer, including breast cancer, lung cancer, and melanoma. While it has shown promise in preclinical studies, its clinical development has faced challenges, including issues related to its formulation and toxicity.
Related Compounds[edit | edit source]
Other derivatives of geldanamycin, such as 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin), have also been developed to improve the pharmacological properties and reduce the toxicity associated with 17-AAG.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
