2'-Oxo-PCE

2'-Oxo-PCE (also known as Deschloroeticyclidine or O-PCE) is a dissociative anesthetic that has been sold online as a designer drug. It is a close analogue of Eticyclidine (PCE), but with one of the chlorine atoms replaced by an oxygen atom.

Chemistry

2'-Oxo-PCE is a member of the arylcyclohexylamine class, which also includes other dissociative anesthetics such as ketamine and phencyclidine (PCP). The structure of 2'-Oxo-PCE consists of a phenyl ring bonded to a cyclohexane ring, which is in turn bonded to an amino group. The difference between 2'-Oxo-PCE and its parent compound, PCE, is the replacement of a chlorine atom with an oxygen atom.

Pharmacology

Like other dissociative anesthetics, 2'-Oxo-PCE is thought to primarily act as an NMDA receptor antagonist. This means it blocks the action of the neurotransmitter glutamate at the NMDA receptor, which is responsible for sensation, memory, and consciousness. By blocking this receptor, 2'-Oxo-PCE produces a state of dissociation, or disconnection from one's physical surroundings and sense of self.

Effects

The effects of 2'-Oxo-PCE can vary greatly depending on the dose, but generally include feelings of derealization and depersonalization, hallucinations, and a loss of motor control. At higher doses, it can cause a complete loss of sensory perception, known as a "K-hole". These effects can be intense and long-lasting, and have led to hospitalizations and deaths in some cases.

Legal Status

The legal status of 2'-Oxo-PCE varies by country. In some countries, such as the United States, it is not specifically controlled but may be considered an analogue of a controlled substance under the Federal Analogue Act. In other countries, such as the United Kingdom, it is a Class B drug under the Misuse of Drugs Act.

See Also

• Arylcyclohexylamine
• Dissociative
• Designer drug
• NMDA receptor antagonist