2′-NH2-MPTP
Chemical compound
2′-NH₂-MPTP[edit | edit source]
2′-NH₂-MPTP, or 2′-amino-MPTP, is a chemical compound that is structurally related to the neurotoxin MPTP. It is of interest in the field of neuropharmacology due to its potential effects on the central nervous system and its relationship to Parkinson's disease.
Chemical Structure and Properties[edit | edit source]
2′-NH₂-MPTP is a derivative of MPTP, with an amino group attached to the 2′ position of the molecule. This modification alters its chemical properties and potentially its biological activity. The presence of the amino group can affect the compound's solubility, reactivity, and interaction with biological targets.
Biological Activity[edit | edit source]
The biological activity of 2′-NH₂-MPTP is of particular interest because of its structural similarity to MPTP, a compound known to induce Parkinsonism in humans and other primates. MPTP itself is metabolized in the brain to form MPP⁺, a potent neurotoxin that selectively destroys dopaminergic neurons in the substantia nigra, leading to symptoms similar to those of Parkinson's disease.
2′-NH₂-MPTP may undergo similar metabolic pathways, but the presence of the amino group could influence its conversion to active metabolites and its overall neurotoxic potential. Research into 2′-NH₂-MPTP aims to understand these metabolic pathways and their implications for neurodegeneration.
Research and Implications[edit | edit source]
Studies on 2′-NH₂-MPTP contribute to the broader understanding of neurotoxins and their role in neurodegenerative diseases. By examining how structural modifications affect the activity of MPTP-like compounds, researchers can gain insights into the mechanisms of neuronal damage and potential therapeutic targets for conditions like Parkinson's disease.
The compound also serves as a tool in experimental models to study the pathophysiology of Parkinsonism and to test potential neuroprotective agents. Understanding the differences in toxicity and metabolism between MPTP and its derivatives like 2′-NH₂-MPTP can help in developing safer compounds for research and therapeutic use.
Related Compounds[edit | edit source]
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
