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2,2'-Difluorofentanyl is a synthetic opioid analgesic that is structurally related to fentanyl. It is part of the fentanyl analogs, which are a class of potent synthetic opioids used primarily for pain management and anesthesia.

Chemical Structure[edit | edit source]

2,2'-Difluorofentanyl has a chemical structure similar to fentanyl, with the primary difference being the substitution of two fluorine atoms at the 2,2' positions on the phenethyl ring. The IUPAC name for 2,2'-Difluorofentanyl is N-(1-(2,2-difluorophenethyl)piperidin-4-yl)-N-phenylpropionamide.

Pharmacology[edit | edit source]

As an opioid, 2,2'-Difluorofentanyl acts on the mu-opioid receptor in the central nervous system to produce analgesic effects. The potency and efficacy of 2,2'-Difluorofentanyl are influenced by its chemical structure, which allows it to bind more effectively to opioid receptors compared to other opioids.

Medical Use[edit | edit source]

2,2'-Difluorofentanyl, like other fentanyl analogs, is used in medical settings for the management of severe pain, particularly in patients who are tolerant to other opioids. It is also used in anesthesia to provide pain relief during surgical procedures.

Side Effects[edit | edit source]

The side effects of 2,2'-Difluorofentanyl are similar to those of other opioids and can include:

Legal Status[edit | edit source]

Due to its high potency and potential for abuse, 2,2'-Difluorofentanyl is regulated under various national and international drug control laws. It is classified as a controlled substance in many countries, requiring special licensing for its manufacture, distribution, and use.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Bonnu, Prab R. Tumpati, MD