From WikiMD's Food, Medicine & Wellness Encyclopedia

2,4,6-Tribromophenol (2,4,6-TBP) is an organic compound with the formula C_6H_2Br_3OH. It is one of the brominated derivatives of phenol. The substance is a white solid at room temperature, exhibiting a slight, characteristic odor. It is primarily used as a fungicide, pesticide, and a precursor to other chemical compounds. Due to its widespread use, 2,4,6-TBP has been detected in various environmental settings and has raised concerns regarding its impact on human health and the environment.

Properties[edit | edit source]

2,4,6-Tribromophenol has a molecular weight of 330.79 g/mol and a melting point of 93-95 °C. It is sparingly soluble in water but has good solubility in organic solvents such as ethanol, diethyl ether, and acetone. The presence of three bromine atoms in its structure makes it a relatively reactive compound, capable of undergoing various chemical transformations.

Synthesis[edit | edit source]

2,4,6-TBP is synthesized through the direct bromination of phenol, where phenol is treated with bromine in the presence of a catalyst such as iron(III) bromide. The reaction yields a mixture of brominated phenols, from which 2,4,6-TBP can be isolated through various separation techniques.

Applications[edit | edit source]

The primary use of 2,4,6-tribromophenol is as a fungicide and pesticide. It is also employed in the production of fire retardants through its conversion to more complex brominated compounds. In addition, 2,4,6-TBP serves as an intermediate in the synthesis of other organic compounds, including pharmaceuticals and dyes.

Environmental Impact and Health Concerns[edit | edit source]

2,4,6-Tribromophenol has been detected in various environmental matrices, including water, soil, and air. Its persistence and potential for bioaccumulation raise concerns about its environmental impact. Exposure to 2,4,6-TBP can occur through ingestion, inhalation, or dermal contact, leading to potential health risks such as endocrine disruption and toxicity to the liver and kidneys. The compound has been found in human tissues and fluids, indicating its widespread presence and potential for human exposure.

Regulation[edit | edit source]

Due to its potential health and environmental risks, the use and disposal of 2,4,6-TBP are regulated in many countries. Guidelines and limits have been established for its presence in air, water, and soil to minimize human and ecological exposure.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD