2-Aminoethoxydiphenyl borate
Chemical compound
2-Aminoethoxydiphenyl borate (2-APB) is a chemical compound that is commonly used in biological research as a modulator of calcium signaling. It is known for its ability to influence the activity of ion channels and receptors involved in calcium homeostasis.
Chemical Structure[edit | edit source]
2-APB is an organic compound with the chemical formula C14H15BNO2. It consists of a borate group attached to a diphenyl ether moiety, with an aminoethoxy side chain. The presence of the boron atom is crucial for its biological activity.
Mechanism of Action[edit | edit source]
2-APB is primarily known for its role as an inhibitor of IP3 receptors (IP3Rs) and store-operated calcium entry (SOCE). It can modulate the release of calcium from the endoplasmic reticulum by inhibiting IP3Rs, which are channels that release calcium in response to IP3 signaling.
Additionally, 2-APB affects SOCE by interacting with the stromal interaction molecule (STIM) and Orai proteins, which are essential components of the calcium release-activated calcium (CRAC) channel. By modulating these pathways, 2-APB can influence various cellular processes that depend on calcium signaling.
Applications in Research[edit | edit source]
2-APB is widely used in pharmacology and cell biology to study calcium signaling pathways. It serves as a tool to dissect the roles of IP3Rs and SOCE in various physiological and pathological contexts. Researchers utilize 2-APB to:
- Investigate the dynamics of calcium release and uptake in cells.
- Explore the role of calcium signaling in apoptosis, cell proliferation, and differentiation.
- Study the effects of calcium modulation in neurobiology and cardiology.
Limitations[edit | edit source]
While 2-APB is a valuable research tool, it is not highly selective and can affect multiple targets within the cell. This lack of specificity can complicate the interpretation of experimental results. Researchers must consider these limitations when designing experiments and analyzing data.
Related pages[edit | edit source]
Gallery[edit | edit source]
2D structure of 2-APB
3D space-filling model of 2-APB
2-Aminoethoxydiphenyl_borate[edit | edit source]
2-APB
2-APB 3D spacefill
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