2-Aminoethoxydiphenyl borate
Chemical compound
2-Aminoethoxydiphenyl borate (2-APB) is a chemical compound that is commonly used in biological research as a modulator of calcium signaling. It is known for its ability to influence the activity of ion channels and receptors involved in calcium homeostasis.
Chemical Structure[edit | edit source]
2-APB is an organic compound with the chemical formula C14H15BNO2. It consists of a borate group attached to a diphenyl ether moiety, with an aminoethoxy side chain. The presence of the boron atom is crucial for its biological activity.
Mechanism of Action[edit | edit source]
2-APB is primarily known for its role as an inhibitor of IP3 receptors (IP3Rs) and store-operated calcium entry (SOCE). It can modulate the release of calcium from the endoplasmic reticulum by inhibiting IP3Rs, which are channels that release calcium in response to IP3 signaling.
Additionally, 2-APB affects SOCE by interacting with the stromal interaction molecule (STIM) and Orai proteins, which are essential components of the calcium release-activated calcium (CRAC) channel. By modulating these pathways, 2-APB can influence various cellular processes that depend on calcium signaling.
Applications in Research[edit | edit source]
2-APB is widely used in pharmacology and cell biology to study calcium signaling pathways. It serves as a tool to dissect the roles of IP3Rs and SOCE in various physiological and pathological contexts. Researchers utilize 2-APB to:
- Investigate the dynamics of calcium release and uptake in cells.
- Explore the role of calcium signaling in apoptosis, cell proliferation, and differentiation.
- Study the effects of calcium modulation in neurobiology and cardiology.
Limitations[edit | edit source]
While 2-APB is a valuable research tool, it is not highly selective and can affect multiple targets within the cell. This lack of specificity can complicate the interpretation of experimental results. Researchers must consider these limitations when designing experiments and analyzing data.
Related pages[edit | edit source]
Gallery[edit | edit source]
2D structure of 2-APB
3D space-filling model of 2-APB
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
