2-Methoxyestrone

2-Methoxyestrone.svg

2-Methoxyestrone is a methoxylated derivative of the estrogen estrone. It is a naturally occurring estrogen metabolite and is formed from estrone via the action of the enzyme catechol-O-methyltransferase (COMT).

Biochemistry

2-Methoxyestrone is produced in the body through the methylation of 2-hydroxyestrone, a process catalyzed by the enzyme catechol-O-methyltransferase. This reaction is part of the metabolic pathway of estrogens, which includes the conversion of estrone to various hydroxylated and methoxylated derivatives.

Function

The biological activity of 2-Methoxyestrone is not well understood, but it is believed to have weaker estrogenic activity compared to estrone and other estrogens. It may play a role in the regulation of estrogen receptor activity and the modulation of estrogen metabolism.

Clinical significance

The levels of 2-Methoxyestrone and other estrogen metabolites can be measured in the body and may provide information about an individual's hormonal status and metabolic health. Abnormal levels of these metabolites have been associated with various health conditions, including breast cancer and other hormone-related disorders.

See also

• Estrone
• Estrogen
• Catechol-O-methyltransferase
• Estrogen metabolism

References

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