2-Methoxyestrone

2-Methoxyestrone is a naturally occurring estrogen metabolite that is part of the estrone family. It is produced in the body through the process of O-methylation of estrone by the enzyme catechol-O-methyltransferase (COMT).

Metabolism

The metabolism of 2-Methoxyestrone occurs in the liver, where it is converted into 2-Methoxyestradiol by the enzyme 17β-Hydroxysteroid dehydrogenase. This conversion is a part of the estrogen metabolic pathway.

Biological Activity

2-Methoxyestrone has been found to have anti-proliferative effects, meaning it can inhibit the growth of cells. This has led to research into its potential use as a cancer treatment. However, it is less potent than its metabolite, 2-Methoxyestradiol, which is currently being investigated for its anti-cancer properties.

See Also

• Estrone
• Estrogen
• 2-Methoxyestradiol
• Catechol-O-methyltransferase
• 17β-Hydroxysteroid dehydrogenase

References

2-Methoxyestrone Resources
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