2-Methyl-DMT

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2-Methyl-DMT (2-Me-DMT, N-methyl-N-isopropyltryptamine) is a psychedelic drug and a lesser-known structural analog of dimethyltryptamine (DMT). It belongs to the tryptamine class of compounds, which are a group of monoamine alkaloids. This compound is of interest in pharmacology and neuroscience for its potential to elucidate the mechanisms of psychedelic experiences and for its potential therapeutic applications.

Chemistry[edit | edit source]

2-Methyl-DMT is a synthetic compound that shares a core structure with other tryptamines, characterized by a tryptamine backbone. The chemical name for 2-Methyl-DMT is N-methyl-N-isopropyltryptamine, indicating the presence of a methyl group attached to the nitrogen atom of the tryptamine's ethylamine side chain, and an isopropyl group replacing one of the hydrogen atoms on the other nitrogen atom. This modification alters the compound's pharmacological profile compared to DMT.

Pharmacology[edit | edit source]

The pharmacological action of 2-Methyl-DMT, like other psychedelic tryptamines, is believed to be primarily through agonism of the serotonin 5-HT2A receptor. However, the presence of the methyl and isopropyl groups may affect its affinity and efficacy at this and other serotonin receptors, potentially altering its psychoactive effects. The exact pharmacological profile of 2-Methyl-DMT remains under-researched, and much of what is known is extrapolated from studies on DMT and related compounds.

Effects[edit | edit source]

The psychoactive effects of 2-Methyl-DMT are presumed to be similar to those of DMT, which include altered perception of time and space, intense visual hallucinations, and profound changes in thought and mood. However, the specific effects, potency, and duration of 2-Methyl-DMT have not been well-documented in the scientific literature, and reports from individuals who have used the substance are scarce and anecdotal.

Legal Status[edit | edit source]

The legal status of 2-Methyl-DMT varies by country, but it may be controlled under analog acts or specific drug legislation that covers tryptamines and their derivatives. In jurisdictions where DMT is illegal, 2-Methyl-DMT is likely to be similarly controlled, though specific information should be verified according to local laws.

Research and Potential Therapeutic Uses[edit | edit source]

Research into 2-Methyl-DMT and other novel tryptamines is part of a broader interest in the therapeutic potential of psychedelics for treating conditions such as depression, anxiety, and PTSD. However, the research on 2-Methyl-DMT specifically is limited, and much more work is needed to understand its effects, safety profile, and potential medical applications.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD