20β-Dihydroprogesterone

20β-Dihydroprogesterone is a biologically active metabolite of progesterone. It is a steroid hormone that plays a significant role in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

Chemistry

20β-Dihydroprogesterone, also known as 20β-OHP, is a naturally occurring progestogen related to progesterone. It is structurally similar to progesterone, with the only difference being the addition of a hydroxyl group at the 20β position.

Biosynthesis

20β-Dihydroprogesterone is synthesized from progesterone in the corpus luteum and the placenta by the enzyme 20β-hydroxysteroid dehydrogenase. This enzyme catalyzes the reduction of the keto group at the 20 position of progesterone to a hydroxyl group, resulting in the formation of 20β-dihydroprogesterone.

Biological Activity

20β-Dihydroprogesterone has been found to possess progestogenic activity, similar to that of progesterone. It is involved in the regulation of the menstrual cycle and plays a crucial role in maintaining pregnancy. It also has a role in the development of the embryo and fetus during pregnancy.

Clinical Significance

The levels of 20β-dihydroprogesterone can be used as a biomarker for various conditions. Elevated levels may indicate luteal phase defect, polycystic ovary syndrome, or endometriosis. It can also be used to monitor the health of a pregnancy, as low levels may indicate a risk of miscarriage.

See Also

• Progesterone
• 20β-hydroxysteroid dehydrogenase
• Steroid hormone
• Menstrual cycle
• Pregnancy