20-Methylcholanthrene

20-Methylcholanthrene (20-MC) is a carcinogen that is often used in scientific research to induce tumors in laboratory animals. It is a derivative of cholanthrene, a type of polycyclic aromatic hydrocarbon (PAH).

Chemical Structure and Properties

20-Methylcholanthrene is a polycyclic aromatic hydrocarbon with the molecular formula C21H16. It is a solid, crystalline substance that is insoluble in water but soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). Its chemical structure consists of five fused rings, with a methyl group attached to the 20th carbon atom.

Biological Effects

20-Methylcholanthrene is a potent carcinogen. It can induce the formation of tumors in various tissues, including the lung, skin, and mammary gland. The carcinogenic effects of 20-MC are thought to be due to its ability to form DNA adducts, which can lead to mutations and the activation of oncogenes.

Use in Research

20-Methylcholanthrene is commonly used in research to study the mechanisms of carcinogenesis. It is often used to induce tumors in laboratory animals, which can then be studied to gain insights into the processes that lead to the development of cancer.

Safety

Due to its carcinogenic properties, 20-Methylcholanthrene should be handled with care. It is classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), which means it is known to cause cancer in humans.

See Also

• Polycyclic aromatic hydrocarbon
• Carcinogen
• Tumor

References

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