20-hydroxysteroid dehydrogenase

From WikiMD's Food, Medicine & Wellness Encyclopedia

20-Hydroxysteroid dehydrogenase (20-HSD) is an enzyme that catalyzes the conversion of steroid hormones. It is a member of the dehydrogenase family of enzymes, which are responsible for the oxidation of a wide range of substances in the body.

Function[edit | edit source]

20-Hydroxysteroid dehydrogenase plays a crucial role in the metabolism of steroid hormones. It catalyzes the conversion of 20-hydroxysteroids to ketosteroids, a process that is essential for the regulation of steroid hormone levels in the body. This enzyme is found in various tissues, including the liver, kidney, and adrenal gland.

Structure[edit | edit source]

The structure of 20-HSD is similar to other dehydrogenase enzymes. It is a protein composed of several amino acid sequences, which form a three-dimensional structure. The active site of the enzyme, where the catalytic reaction takes place, contains a cofactor that assists in the conversion of the substrate.

Clinical significance[edit | edit source]

Alterations in the activity of 20-HSD have been associated with various health conditions. For instance, increased activity of this enzyme has been linked to polycystic ovary syndrome, a condition characterized by elevated levels of androgens. On the other hand, decreased activity of 20-HSD may lead to corticosteroid deficiency.

Research[edit | edit source]

Research on 20-HSD is ongoing, with scientists aiming to understand more about its role in steroid hormone metabolism and its potential as a therapeutic target for various diseases.


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Contributors: Prab R. Tumpati, MD