3',4'-Dimethoxy-α-pyrrolidinopentiophenone

3',4'-Dimethoxy-α-pyrrolidinopentiophenone (3',4'-DMeO-α-PVP), also known as 3',4'-dimethoxy-α-pyrrolidinovalerophenone, is a synthetic stimulant of the cathinone class developed in the 1960s that has been reported as a novel psychoactive substance. It is closely related to other synthetic compounds that act as neurotransmitter reuptake inhibitors, such as α-PVP and MDPV. These substances are known for their potent psychoactive effects, primarily inducing stimulant and euphoric sensations.

Chemistry

3',4'-DMeO-α-PVP is a derivative of α-PVP, which itself is a synthetic derivative of cathinone, a compound found in the khat plant. The chemical structure of 3',4'-DMeO-α-PVP includes a pyrrolidine ring—a five-membered nitrogen-containing ring—attached to the pentiophenone segment of the molecule. The presence of methoxy groups at the 3' and 4' positions of the phenyl ring distinguishes it from its parent compound, α-PVP, and is believed to affect its pharmacological profile.

Pharmacology

The pharmacological activity of 3',4'-DMeO-α-PVP is primarily attributed to its ability to inhibit the reuptake of key neurotransmitters, notably dopamine and norepinephrine, leading to an increase in their concentrations in the synaptic cleft and subsequent stimulation of the central nervous system. This mechanism of action is similar to that of other known cathinones, which can produce intense stimulant effects, including increased energy, alertness, and euphoria, but also potential for adverse effects such as tachycardia, hypertension, and psychosis.

Legal Status

The legal status of 3',4'-DMeO-α-PVP varies by country, with many jurisdictions having enacted controls on cathinones and their derivatives due to concerns over their potential for abuse and harm. In some countries, it is classified as a controlled substance, making its manufacture, distribution, and possession illegal without authorization.

Health Risks

The use of 3',4'-DMeO-α-PVP, like other synthetic cathinones, is associated with significant health risks. Adverse effects can include psychological effects such as anxiety, paranoia, and hallucinations, as well as physical effects like increased heart rate, high blood pressure, and in severe cases, overdose leading to potentially fatal outcomes. The lack of research on its long-term effects also poses a significant risk to users.

See Also

• Cathinone
• α-PVP
• MDPV
• Synthetic cathinones
• Psychoactive substance