3β-Androstanediol

3β-Androstanediol is a steroid and metabolite of testosterone. It is classified as an androgen and neurosteroid, and is a precursor to progesterone. It is found in the body naturally and is also available as a pharmaceutical drug.

Structure and Synthesis

3β-Androstanediol is a steroid with a structure similar to that of testosterone. It is synthesized from testosterone via the enzyme 5α-reductase, which converts testosterone into dihydrotestosterone (DHT). DHT is then converted into 3β-androstanediol by the enzyme 3β-hydroxysteroid dehydrogenase.

Function

3β-Androstanediol has multiple functions in the body. As an androgen, it contributes to the development and maintenance of male secondary sexual characteristics. As a neurosteroid, it has effects on the nervous system, including neuroprotection and modulation of neurotransmission. It is also a precursor to progesterone, a hormone that plays key roles in the menstrual cycle, pregnancy, and embryogenesis.

Medical Use

3β-Androstanediol is used in medicine as a hormone replacement therapy for men with androgen deficiency. It is also used in the treatment of breast cancer and prostate cancer, due to its ability to inhibit the growth of these types of cancer cells.

Side Effects

Potential side effects of 3β-androstanediol include acne, hair loss, and gynecomastia. Long-term use can lead to cardiovascular disease and liver damage.

See Also

• Testosterone
• Dihydrotestosterone
• Progesterone
• Androgen deficiency
• Breast cancer
• Prostate cancer

3β-Androstanediol Resources
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