3,3'-Diindolylmethane

3,3'-Diindolylmethane (also known as DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and kale. The reputation of Brassica vegetables as healthy foods rests in part on the activities of diindolylmethane.

Chemistry

DIM is produced from a chemical reaction that occurs during the digestion of indole-3-carbinol, which is found in cruciferous vegetables. The reaction is catalyzed by stomach acid.

Health Effects

DIM has been shown to have several effects on cellular activity in vitro, including the promotion of apoptosis and the inhibition of cell cycle progression. However, the relevance of these effects to human health are not yet clear.

Research

Research on DIM has been conducted in relation to its potential anti-cancer effects, its effect on steroid hormone metabolism, and its anti-inflammatory effects. However, the results of these studies have been mixed and further research is needed.

Safety

DIM is considered safe for most people when consumed in amounts typically found in the diet. However, it can cause side effects such as skin rash and small increases in liver enzymes in some people.

See Also

• Indole-3-carbinol
• Cruciferous vegetables
• Apoptosis
• Cell cycle

References

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  3,3'-Diindolylmethane