Indole-3-carbinol

Indole-3-carbinol (I3C) is a compound naturally occurring in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. It is produced when these vegetables are chopped, chewed, or cooked. I3C is a subject of scientific research, as it has been found to have potential health benefits, including possible cancer prevention properties.

Chemical Structure and Properties

Indole-3-carbinol is a member of the class of compounds known as indoles. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The carbinol part of the molecule refers to the hydroxyl (-OH) group attached to the carbon at the 3-position of the indole ring.

Sources and Intake

The primary dietary sources of indole-3-carbinol are cruciferous vegetables, including broccoli, Brussels sprouts, cabbage, cauliflower, kale, and collard greens. The amount of I3C in these foods can vary depending on factors such as the specific type of vegetable, its maturity, and the way it is prepared.

Health Benefits

Research has suggested that indole-3-carbinol may have several health benefits. It has been found to have antioxidant properties, meaning it can neutralize harmful free radicals in the body. I3C has also been shown to have anti-inflammatory effects, which may help to reduce the risk of diseases such as heart disease and cancer.

One of the most significant areas of research regarding I3C is its potential role in cancer prevention. Some studies have suggested that it may help to prevent or slow the growth of certain types of cancer, including breast, prostate, and colorectal cancer. However, more research is needed to confirm these findings and to understand the mechanisms by which I3C may exert these effects.

Safety and Side Effects

Indole-3-carbinol is generally considered safe when consumed in amounts typically found in foods. However, taking I3C supplements can cause side effects in some people, including skin rashes and digestive problems. High doses of I3C can also affect hormone levels, which can have various effects on the body.

See Also

• Cruciferous vegetables
• Indoles
• Antioxidants
• Cancer prevention