3,4-Dichlorophenylpiperazine

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3,4-Dichlorophenylpiperazine (3,4-DCPP or DCPP) is a chemical compound that belongs to the class of organic compounds known as piperazines. Piperazines are compounds containing a piperazine ring, a six-membered ring with two nitrogen atoms and four carbon atoms.

Chemical Structure[edit | edit source]

The chemical structure of 3,4-Dichlorophenylpiperazine consists of a piperazine ring substituted with a phenyl group at one nitrogen atom and two chlorine atoms at the 3 and 4 positions of the phenyl ring. The systematic name of this compound is 1-(3,4-dichlorophenyl)piperazine.

Synthesis[edit | edit source]

The synthesis of 3,4-Dichlorophenylpiperazine typically involves the reaction of 3,4-dichloroaniline with sodium nitrite and hydrochloric acid to form the corresponding diazonium salt, which is then treated with piperazine to give the desired product.

Applications[edit | edit source]

3,4-Dichlorophenylpiperazine has been used as a starting material in the synthesis of various pharmaceutical drugs, including antidepressants and antipsychotics. It is also used in the production of pesticides and other agrochemicals.

Safety and Toxicity[edit | edit source]

Like other piperazine derivatives, 3,4-Dichlorophenylpiperazine can be toxic if ingested or inhaled, and can cause irritation to the skin and eyes. It is recommended to handle this compound with appropriate safety precautions.

Regulation[edit | edit source]

In some countries, 3,4-Dichlorophenylpiperazine is regulated due to its potential use in the illicit manufacture of psychoactive drugs.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD