3-Hydroxyphenazepam
A benzodiazepine derivative
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3-Hydroxyphenazepam is a benzodiazepine derivative that has been studied for its pharmacological properties. It is a metabolite of the drug phenazepam, which is used in some countries for its anxiolytic, anticonvulsant, and muscle relaxant properties.
Chemical structure and properties[edit | edit source]
3-Hydroxyphenazepam is characterized by its chemical structure, which includes a bromine atom at the 7-position and a chlorine atom at the 2-position of the phenyl ring. The presence of the hydroxy group at the 3-position of the benzodiazepine core is a distinguishing feature of this compound.
Pharmacology[edit | edit source]
As a benzodiazepine, 3-Hydroxyphenazepam acts on the central nervous system by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This action results in its sedative, anxiolytic, and muscle relaxant effects. The pharmacokinetics and specific receptor binding affinities of 3-Hydroxyphenazepam are subjects of ongoing research.
Metabolism[edit | edit source]
3-Hydroxyphenazepam is a primary metabolite of phenazepam. The metabolic pathway involves the hydroxylation of phenazepam, which is then excreted in the urine. Understanding the metabolism of benzodiazepines is crucial for interpreting drug tests and managing potential drug interactions.
Legal status[edit | edit source]
The legal status of 3-Hydroxyphenazepam varies by country. In some jurisdictions, it may be controlled under laws regulating benzodiazepines due to its potential for abuse and dependence.
Related compounds[edit | edit source]
3-Hydroxyphenazepam is related to other benzodiazepines such as diazepam, lorazepam, and alprazolam. These compounds share similar mechanisms of action but differ in their pharmacokinetic profiles and clinical uses.
See also[edit | edit source]
Related pages[edit | edit source]
Chemical structure of 3-Hydroxyphenazepam
Ball-and-stick model of 3-Hydroxyphenazepam
3-Hydroxyphenazepam[edit | edit source]
3-Hydroxyphenazepam chemical structure
3-Hydroxyphenazepam ball-and-stick model
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