3-Keto-5α-abiraterone
3-Keto-5α-abiraterone is a biologically active metabolite of abiraterone, a steroid inhibitor used in the treatment of prostate cancer. It is produced in the body by the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD).
Chemistry[edit | edit source]
3-Keto-5α-abiraterone is a steroid metabolite, meaning it is derived from a parent compound through metabolic processes. It is a ketone, as indicated by the "3-Keto" in its name, and is a 5α-isomer of abiraterone.
Pharmacology[edit | edit source]
3-Keto-5α-abiraterone is a potent inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme that plays a crucial role in the biosynthesis of all classes of hormonal steroids. By inhibiting this enzyme, 3-Keto-5α-abiraterone can reduce the production of androgens, which are hormones that stimulate the growth of prostate cancer cells.
Clinical significance[edit | edit source]
The clinical significance of 3-Keto-5α-abiraterone lies in its potential use as a therapeutic agent in the treatment of prostate cancer. Its parent compound, abiraterone, is already used in the treatment of this disease, and the production of 3-Keto-5α-abiraterone as a metabolite may contribute to the effectiveness of this treatment.
See also[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD