4-bromo-2,5-dimethoxy-amphetamine

4-Bromo-2,5-dimethoxyamphetamine (4-Bromo-2,5-DMA), also known as DOB, is a psychedelic drug belonging to the amphetamine class of compounds. It is known for its potent psychoactive properties, which include alterations in perception, consciousness, and cognition. DOB was first synthesized by Alexander Shulgin, a chemist and pharmacologist, and is detailed in his book PiHKAL (Phenethylamines I Have Known And Loved).

Chemistry

4-Bromo-2,5-dimethoxyamphetamine is a synthetic compound that belongs to the substituted amphetamines group, which are derivatives of amphetamine where the phenethylamine core structure is modified by substituting various groups at specific positions. In the case of DOB, a bromo atom is attached at the 4 position of the benzene ring, and two methoxy groups are attached at the 2 and 5 positions, respectively. This chemical structure is responsible for its potent psychoactive effects.

Pharmacology

The pharmacological action of DOB is primarily as a serotonin receptor agonist, with a particular affinity for the 5-HT2A receptor. Activation of this receptor is believed to be responsible for the drug's psychedelic effects. DOB is known for its long duration of action, typically lasting 12 to 24 hours, which is significantly longer than many other psychedelics.

Effects

The effects of DOB can vary greatly depending on the dose, setting, and individual physiology. Commonly reported effects include visual hallucinations, enhanced colors, emotional uplift, euphoria, and altered perception of time. However, due to its potency and long duration, DOB can also lead to negative effects such as anxiety, paranoia, and uncomfortable physical sensations.

Legal Status

The legal status of 4-Bromo-2,5-dimethoxyamphetamine varies by country, but it has been classified as a controlled substance in many parts of the world due to its potential for abuse and lack of accepted medical use. In the United States, DOB is listed as a Schedule I controlled substance, making its manufacture, distribution, and possession illegal.

Safety

As with all psychoactive substances, the safety of DOB depends on various factors including dosage, individual sensitivity, and context of use. Due to its high potency and long duration of action, there is a higher risk of experiencing adverse effects, particularly at higher doses. It is important for users to exercise caution and adhere to harm reduction practices when using substances like DOB.