5α-Dihydroethisterone

5α-Dihydroethisterone is a steroid and androgen that is derived from ethisterone, a progestin and progestogen. It is a major active metabolite of ethisterone and is thought to contribute to its effects.

Chemistry

5α-Dihydroethisterone, also known as 17α-ethinyl-5α-androstan-17β-ol-3-one, is a synthetic androstane steroid and a derivative of testosterone. It is more specifically a derivative of ethisterone (17α-ethinyltestosterone), and is formed from ethisterone in the body by 5α-reductase.

Pharmacology

5α-Dihydroethisterone has been found to possess relatively high androgenic activity. It is a major active metabolite of ethisterone, and is thought to contribute significantly to the androgenic effects of this compound.

History

5α-Dihydroethisterone was first synthesized in 1938, along with ethisterone, by the German pharmaceutical company Schering AG. It was one of the first synthetic androgens to be introduced for medical use.

See also

• List of androgens/anabolic steroids
• List of androgen esters
• List of progestogens
• List of progestogen esters

References

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