5,7-dihydroxytryptamine

5,7-Dihydroxytryptamine (5,7-DHT) is a neurotoxin that is used in scientific research to decrease the levels of serotonin in the brain. It is derived from the amino acid tryptophan and is known to cause damage to the serotonin neurons in the brain.

Chemical Structure and Properties

5,7-DHT is a derivative of the amino acid tryptophan. It has two hydroxyl groups attached to the 5th and 7th carbon atoms of the indole ring structure, hence the name 5,7-dihydroxytryptamine. The presence of these hydroxyl groups makes the molecule more polar and allows it to cross the blood-brain barrier.

Mechanism of Action

5,7-DHT acts by being taken up into serotonin neurons via the serotonin transporter. Once inside the neuron, it is metabolized into a reactive oxygen species that causes oxidative damage to the neuron, leading to cell death. This results in a decrease in the levels of serotonin in the brain.

Uses in Research

In scientific research, 5,7-DHT is used to create animal models of serotonin deficiency. This is useful for studying the role of serotonin in various physiological processes and in the pathophysiology of various diseases, such as depression, anxiety disorders, and Parkinson's disease.

Safety and Toxicity

5,7-DHT is a neurotoxin and can cause damage to the serotonin neurons in the brain. Therefore, it should be handled with care and appropriate safety measures should be taken when using it in research.

See Also

• Serotonin
• Neurotoxin
• Tryptophan