5-HT1E

5-HT1E is a subtype of the 5-HT1 receptor that binds to the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and inhibits the production of cAMP. The 5-HT1E receptor is expressed in various areas of the brain, but its function is still not fully understood.

Structure

The 5-HT1E receptor is a protein that is encoded by the HTR1E gene. It is a member of the GPCR family, which are characterized by seven transmembrane domains, an extracellular N terminus, and an intracellular C terminus. The receptor is coupled to the Gi/Go protein, which inhibits the production of cAMP when activated.

Function

The 5-HT1E receptor binds to the neurotransmitter serotonin. This binding triggers a series of events that ultimately leads to the inhibition of cAMP production. However, the exact function of the 5-HT1E receptor in the brain is still not fully understood. Some studies suggest that it may play a role in mood regulation, anxiety, and depression.

Clinical significance

Due to its potential role in mood regulation, anxiety, and depression, the 5-HT1E receptor is a potential target for the treatment of these conditions. However, more research is needed to fully understand the function of this receptor and how it can be targeted for therapeutic purposes.

See also

• 5-HT receptor
• Serotonin
• G protein-coupled receptor
• Neurotransmitter

References

5-HT1E Resources
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