5-HT2A

5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor. This receptor is linked to a variety of cognitive and physiological functions.

Function

The 5-HT2A receptor is known for its significant role in the functioning of the central nervous system. It is involved in various cognitive processes including learning, memory, and attention. The receptor is also implicated in the pathophysiology of several psychiatric disorders, including schizophrenia, depression, and anxiety.

Pharmacology

The 5-HT2A receptor is the primary target of several hallucinogenic substances, including LSD and psilocybin. These substances act as agonists at the 5-HT2A receptor, leading to altered perception and cognition. Antagonists of the 5-HT2A receptor are used in the treatment of psychiatric disorders. Some examples include atypical antipsychotics and certain antidepressants.

Genetics

The 5-HT2A receptor is encoded by the HTR2A gene. Variations in this gene have been associated with susceptibility to psychiatric disorders, although the exact mechanisms remain unclear.

See also

• 5-HT receptor
• Serotonin
• G protein-coupled receptor

References

5-HT2A Resources
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