5-HT2B

5-HT2B receptor is a protein that in humans is encoded by the HTR2B gene. It is a subtype of the 5-HT2 receptor that binds the neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT). The 5-HT2B receptor is found in many tissues, including the central nervous system, stomach, and heart.

Function[edit | edit source]

The 5-HT2B receptor regulates several important physiological functions. In the central nervous system, it affects neural plasticity, neuronal excitability, and the release of various neurotransmitters. In the stomach, it regulates gastric motility. In the heart, it has a role in cardiac development and function.

Clinical significance[edit | edit source]

Alterations in 5-HT2B receptor function can have significant clinical implications. Overactivity of this receptor has been linked to conditions such as pulmonary arterial hypertension and cardiac valvulopathy. Certain drugs, including some used for migraine and Parkinson's disease, can affect the function of the 5-HT2B receptor.

Pharmacology[edit | edit source]

Several drugs act on the 5-HT2B receptor. Agonists increase the activity of the receptor, while antagonists decrease it. Some of these drugs are used therapeutically, while others have recreational or experimental uses.

References[edit | edit source]

External links[edit | edit source]

HTR2B at the US National Library of Medicine Medical Subject Headings (MeSH)

5-HT2B Resources
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