5-Methoxy-diisopropyltryptamine

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5-Methoxy-diisopropyltryptamine (5-MeO-DIPT), also known as foxy methoxy, is a psychedelic compound of the tryptamine class. It is known for its hallucinogenic effects similar to those of LSD and psilocybin. Despite its popularity in the early 2000s as a designer drug, it has been made illegal in many countries due to concerns over safety and potential for abuse.

Chemistry[edit | edit source]

5-MeO-DIPT is a synthetic compound structurally related to the tryptamine family, which includes naturally occurring substances like dimethyltryptamine (DMT) and psilocybin. Its molecular formula is C17H26N2O, indicating the presence of two isopropyl groups attached to the nitrogen atom of the tryptamine backbone, and a methoxy group attached to the 5th carbon of the indole ring.

Pharmacology[edit | edit source]

The pharmacological action of 5-MeO-DIPT is primarily through its agonist activity at the serotonin receptors, particularly the 5-HT2A receptor. This action is similar to other psychedelics, which leads to its hallucinogenic effects. The exact mechanism of action is not fully understood, but it is believed to involve changes in brain chemistry and perception, leading to altered states of consciousness.

Effects[edit | edit source]

The effects of 5-MeO-DIPT can vary greatly among individuals, but commonly include hallucinations, enhanced tactile sensations, euphoria, empathy, and altered perception of time and space. The onset of effects typically occurs within 30 minutes to an hour after ingestion, with the experience lasting between 4 to 6 hours. However, these effects can be unpredictable and, in some cases, lead to negative experiences such as anxiety, paranoia, and dysphoria.

Risks and Legality[edit | edit source]

The use of 5-MeO-DIPT carries several health risks, including potential for acute psychological effects and long-term mental health issues. Physically, it can lead to increased heart rate, blood pressure, and body temperature, as well as nausea and vomiting. Due to these risks and its potential for abuse, 5-MeO-DIPT has been classified as an illegal substance in many countries, including the United States, where it is listed as a Schedule I controlled substance.

History[edit | edit source]

5-MeO-DIPT was first synthesized in the 1980s and gained popularity as a recreational drug in the late 1990s and early 2000s. Its use was associated with the rave culture and was often distributed in tablet, powder, or liquid form. Following reports of adverse effects and hospitalizations, regulatory agencies began to classify 5-MeO-DIPT as a controlled substance, leading to a decline in its availability and use.

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Contributors: Prab R. Tumpati, MD