5-lipoxygenase-activating protein

5lip

5-Lipoxygenase-Activating Protein

5-Lipoxygenase-Activating Protein (FLAP) is a crucial protein involved in the biosynthesis of leukotrienes, which are lipid mediators derived from arachidonic acid. FLAP plays a key role in the activation of 5-lipoxygenase, an enzyme responsible for the conversion of arachidonic acid into leukotrienes. Leukotrienes are involved in various inflammatory processes and immune responses in the body.

Structure

FLAP is a transmembrane protein that is primarily located in the nuclear envelope and endoplasmic reticulum. It consists of approximately 18 transmembrane helices and has a molecular weight of around 18 kDa.

Function

FLAP acts as a scaffold protein that facilitates the interaction between arachidonic acid and 5-lipoxygenase, leading to the production of leukotrienes. By binding to arachidonic acid, FLAP helps position the substrate for enzymatic conversion by 5-lipoxygenase.

Role in Inflammation

Leukotrienes produced through the action of FLAP and 5-lipoxygenase are potent mediators of inflammation. They play a significant role in the pathogenesis of inflammatory conditions such as asthma, allergic rhinitis, and inflammatory bowel disease.

Clinical Significance

Due to its involvement in inflammatory processes, FLAP has been identified as a potential target for the development of anti-inflammatory drugs. Inhibitors of FLAP activity are being investigated for their therapeutic potential in the treatment of inflammatory disorders.

See Also

• Arachidonic Acid
• Leukotrienes
• 5-Lipoxygenase