5Cl-UR-144

5Cl-UR-144

5Cl-UR-144 is a synthetic cannabinoid that has been identified as a designer drug. It is a derivative of the compound UR-144, which is known for its potent agonistic activity at the cannabinoid receptors. This compound has been encountered in various herbal smoking blends and is often used recreationally for its psychoactive effects.

Chemical Structure and Properties

5Cl-UR-144 is chemically classified as a naphthoylindole. Its structure is characterized by the presence of a naphthalene group attached to an indole core, with a pentyl chain and a chlorine atom at the 5-position of the indole ring. The molecular formula of 5Cl-UR-144 is C21H28ClNO, and it has a molecular weight of 345.91 g/mol.

Pharmacology

5Cl-UR-144 acts as a full agonist at the CB1 and CB2 cannabinoid receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes, including pain sensation, mood regulation, and appetite control. The activation of these receptors by 5Cl-UR-144 leads to its psychoactive effects, which can include euphoria, altered perception, and relaxation.

Legal Status

The legal status of 5Cl-UR-144 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and other novel psychoactive substances.

Health Risks and Toxicity

The use of 5Cl-UR-144 has been associated with a range of adverse health effects. These can include cardiovascular issues, such as tachycardia and hypertension, as well as psychological effects like anxiety, paranoia, and hallucinations. The long-term health effects of 5Cl-UR-144 use are not well understood, but there is concern about its potential for addiction and other negative outcomes.

Detection in Biological Samples

5Cl-UR-144 can be detected in biological samples using various analytical techniques, such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical settings to confirm exposure to the compound.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Designer drugs
• UR-144
• Naphthoylindole