5F-PCN

Overview

5F-PCN is a synthetic cannabinoid that has been used in scientific research and is known for its potent effects on the endocannabinoid system. It is a member of the naphthoylindole family, which is a class of compounds that interact with the cannabinoid receptors in the brain.

Error creating thumbnail:

Chemical structure of 5F-PCN

Chemical Structure

5F-PCN is chemically classified as a naphthoylindole, which is characterized by a naphthalene ring system attached to an indole core. The "5F" in its name indicates the presence of a fluorine atom at the fifth position of the naphthalene ring. This modification is known to influence the compound's binding affinity and activity at the cannabinoid receptors.

Mechanism of Action

5F-PCN acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, memory, and pain sensation. The activation of these receptors by 5F-PCN can lead to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Pharmacology

The pharmacological profile of 5F-PCN includes high affinity binding to the CB1 and CB2 receptors, leading to its potent effects. The compound's lipophilicity allows it to cross the blood-brain barrier efficiently, contributing to its central nervous system effects. The metabolism of 5F-PCN involves hydroxylation and carboxylation, which are typical pathways for synthetic cannabinoids.

Legal Status

Due to its potential for abuse and lack of medical use, 5F-PCN is classified as a controlled substance in many jurisdictions. It is often included in legislation targeting synthetic cannabinoids, which are frequently sold as "legal highs" or "designer drugs."

Health Effects

The use of 5F-PCN has been associated with adverse health effects, including tachycardia, hypertension, and psychosis. These effects are similar to those observed with other synthetic cannabinoids, which can be more potent and unpredictable than natural cannabinoids.

Related Compounds

5F-PCN is structurally related to other synthetic cannabinoids such as JWH-018 and AM-2201. These compounds share similar mechanisms of action and are often studied together in the context of synthetic cannabinoid research.

Related Pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Naphthoylindole