60S ribosomal protein L17

60S ribosomal protein L17 is a protein that in humans is encoded by the RPL17 gene. This protein is a component of the 60S subunit of the ribosome, playing a critical role in the protein synthesis process. Ribosomes, consisting of two subunits, 40S and 60S, are essential for the translation of mRNA into protein. The 60S ribosomal protein L17 is one of the many proteins that make up the larger 60S subunit and contributes to its structure and function.

Function

The primary function of the 60S ribosomal protein L17 is to participate in the assembly and structural integrity of the 60S ribosomal subunit. It is involved in the early stages of ribosome assembly within the nucleolus and is essential for the proper translation of mRNA into proteins. This protein, like other ribosomal proteins, is important for maintaining the correct structure of the ribosome and ensuring the fidelity of protein synthesis.

Gene

The RPL17 gene is located on chromosome 22 in humans. It encodes the 60S ribosomal protein L17, which is highly conserved across different species, indicating its essential role in the ribosome's function. The gene's expression is tightly regulated, ensuring the correct amount of protein is produced for ribosome assembly.

Clinical Significance

Alterations in the expression or mutations in the RPL17 gene can have significant clinical implications. Abnormalities in ribosomal proteins, including L17, have been associated with various diseases, such as cancer and Diamond-Blackfan anemia, a rare disorder characterized by impaired production of red blood cells. Research into the RPL17 gene and its protein product may provide insights into the mechanisms of these diseases and potential therapeutic targets.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins