60S ribosomal protein L36

60S ribosomal protein L36 (RPL36) is a protein that in humans is encoded by the RPL36 gene. This protein is a component of the 60S subunit of the ribosome, playing a role in protein synthesis. Ribosomal proteins are highly conserved components that are essential for ribosome assembly and function. The 60S ribosomal protein L36 is part of the large ribosomal subunit and contributes to the structural and functional integrity of the ribosome.

Function

The 60S ribosomal protein L36 is involved in the assembly and stability of the 60S ribosomal subunit. It participates in the process of translation, facilitating the synthesis of proteins by decoding messenger RNA (mRNA) sequences. The precise role of RPL36 within the ribosome includes interactions with RNA and other ribosomal proteins to ensure accurate amino acid sequencing in newly synthesized proteins.

Gene

The RPL36 gene is located on chromosome 19 in humans. It encodes the ribosomal protein L36, which is one of the many components of the ribosomal 60S subunit. The gene undergoes transcription and translation processes to produce the RPL36 protein, which is then transported to the nucleolus for assembly into ribosomes.

Clinical Significance

Alterations in the expression or function of ribosomal proteins, including RPL36, can lead to diseases known as ribosomopathies. These conditions are characterized by defects in ribosome function and assembly, leading to a variety of clinical manifestations including developmental abnormalities and predisposition to cancer. However, specific diseases directly associated with mutations in the RPL36 gene are not well-documented, highlighting the need for further research in this area.

Evolutionary Conservation

Ribosomal proteins, including RPL36, are highly conserved across different species, reflecting their fundamental role in the cell. The conservation of these proteins supports their essential functions in ribosomal assembly and protein synthesis across eukaryotes and prokaryotes.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins