60S ribosomal protein L37

60S ribosomal protein L37 is a protein that in humans is encoded by the RPL37 gene. This protein is a component of the 60S ribosomal subunit which is part of the ribosome, the cell's molecular machine for protein synthesis. Ribosomal proteins play a key role in the function of the ribosome, facilitating the efficient synthesis of proteins according to the genetic instructions carried by mRNA.

Function

The 60S ribosomal protein L37 is involved in the assembly and function of the 60S subunit of the ribosome. The 60S subunit, together with the 40S ribosomal subunit, forms the complete 80S ribosome in eukaryotic cells. The 60S subunit is responsible for the peptidyl transferase activity, which forms peptide bonds between adjacent amino acids using the mRNA as a template. The specific role of L37 within the 60S subunit includes contributing to the structural integrity of the ribosome and possibly interacting with mRNA and tRNA during translation.

Gene

The RPL37 gene is located on the chromosome 19 in humans. It encodes the 60S ribosomal protein L37. Like other ribosomal proteins, L37 is believed to be highly conserved across different species, indicating its essential role in the ribosome's function.

Clinical Significance

Alterations in the expression of ribosomal proteins, including L37, have been studied in the context of various diseases. While the specific implications of L37 dysregulation are not fully understood, changes in ribosomal protein levels can affect cell growth and proliferation. This has potential implications in cancer and other diseases characterized by abnormal cell growth.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins