7α-Hydroxyepiandrosterone
7α-Hydroxyepiandrosterone (7α-OH-EpiA) is a steroid and a metabolite of the androgen epiandrosterone (EpiA). It is formed from EpiA in the body by the enzyme cytochrome P450 7B1 (CYP7B1).
Structure and Function[edit | edit source]
7α-Hydroxyepiandrosterone is a hydroxylated derivative of epiandrosterone, which is itself a metabolite of dehydroepiandrosterone (DHEA). The hydroxylation at the 7α position, which is catalyzed by the enzyme CYP7B1, significantly alters the molecule's bioactivity.
Bioactivity[edit | edit source]
7α-Hydroxyepiandrosterone has been found to possess anti-glucocorticoid activity. This means it can counteract the effects of glucocorticoids, a class of steroid hormones that are involved in the regulation of metabolism and immune response.
Clinical Significance[edit | edit source]
Research into the clinical significance of 7α-Hydroxyepiandrosterone is ongoing. Some studies suggest that it may have potential therapeutic applications in conditions such as autoimmune diseases, neurodegenerative diseases, and cancer. However, more research is needed to fully understand its role in these conditions.
See Also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
