7α-Hydroxyepiandrosterone

7α-Hydroxyepiandrosterone (7α-OH-EpiA) is a steroid and a metabolite of the androgen epiandrosterone (EpiA). It is formed from EpiA in the body by the enzyme cytochrome P450 7B1 (CYP7B1).

Structure and Function

7α-Hydroxyepiandrosterone is a hydroxylated derivative of epiandrosterone, which is itself a metabolite of dehydroepiandrosterone (DHEA). The hydroxylation at the 7α position, which is catalyzed by the enzyme CYP7B1, significantly alters the molecule's bioactivity.

Bioactivity

7α-Hydroxyepiandrosterone has been found to possess anti-glucocorticoid activity. This means it can counteract the effects of glucocorticoids, a class of steroid hormones that are involved in the regulation of metabolism and immune response.

Clinical Significance

Research into the clinical significance of 7α-Hydroxyepiandrosterone is ongoing. Some studies suggest that it may have potential therapeutic applications in conditions such as autoimmune diseases, neurodegenerative diseases, and cancer. However, more research is needed to fully understand its role in these conditions.

See Also

• Epiandrosterone
• Dehydroepiandrosterone
• Cytochrome P450 7B1

References

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