7,8-DHF
7,8-Dihydroxyflavone (also known as 7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB), which is a receptor for the brain-derived neurotrophic factor (BDNF). It is currently being researched for potential therapeutic use in the treatment of neurodegenerative diseases and psychiatric disorders.
Chemistry[edit | edit source]
7,8-DHF is a flavone, a type of phenolic chemical compound. Flavones are a class of flavonoids, which are a class of compounds with antioxidant effects. Flavones also have potential beneficial health effects.
Pharmacology[edit | edit source]
7,8-DHF acts as a potent and selective agonist for the TrkB receptor, which is a receptor for the BDNF. BDNF is a protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor.
Potential Therapeutic Uses[edit | edit source]
7,8-DHF is currently being researched for potential therapeutic use in the treatment of neurodegenerative diseases and psychiatric disorders. It has been found to have neuroprotective effects in mouse models of neurodegenerative disease. It has also been found to have antidepressant effects in mice.
See Also[edit | edit source]
- Flavonoid
- Tropomyosin receptor kinase B
- Brain-derived neurotrophic factor
- Neurodegenerative diseases
- Psychiatric disorders
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
