7-Chlorokynurenate

7-Chlorokynurenate (also known as 7-CKA) is a synthetic compound that acts as an antagonist for the NMDA receptor, a type of glutamate receptor in the brain. It is a derivative of kynurenic acid, a naturally occurring compound in the body.

Chemistry

7-Chlorokynurenate is a chlorinated derivative of kynurenic acid. The addition of a chlorine atom at the 7 position of the kynurenic acid molecule enhances its antagonistic properties at the NMDA receptor.

Pharmacology

As an NMDA receptor antagonist, 7-Chlorokynurenate inhibits the action of glutamate, the primary excitatory neurotransmitter in the brain. This can have a variety of effects, depending on the dose and the area of the brain where the drug is active.

Therapeutic Potential

Due to its ability to modulate glutamate activity, 7-Chlorokynurenate has been studied for potential therapeutic uses in a variety of neurological and psychiatric disorders, including schizophrenia, Alzheimer's disease, and major depressive disorder. However, more research is needed to fully understand its effects and potential benefits.

Safety and Side Effects

Like other NMDA receptor antagonists, 7-Chlorokynurenate can have side effects, including hallucinations, dizziness, and nausea. It is not currently approved for medical use, and should only be used under the supervision of a healthcare professional.

See Also

• Kynurenic acid
• NMDA receptor antagonist
• Glutamate receptor