7-Methylxanthine

7-Methylxanthine is a xanthine derivative and a metabolite of theobromine and caffeine in some species. It is a naturally occurring substance found in small amounts in various foods and beverages, including chocolate, coffee, and tea.

Chemical Structure

7-Methylxanthine is a methylxanthine that is xanthine substituted by a methyl group at position 7. It has a role as a human metabolite and a mouse metabolite. It is a member of xanthines and a member of methylxanthines.

Metabolism

In humans, 7-methylxanthine is a minor metabolite of caffeine, formed by demethylation. It is further metabolized to xanthine and uric acid. In other species, such as dogs and rats, 7-methylxanthine is a major metabolite of caffeine.

Pharmacology

7-Methylxanthine has been studied for its potential therapeutic uses. It has been found to have bronchodilator effects, similar to other xanthine derivatives such as theophylline. This makes it a potential treatment for conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Toxicity

Like other xanthine derivatives, 7-methylxanthine can have toxic effects at high doses. These can include nausea, vomiting, tachycardia, and seizures. In severe cases, it can lead to cardiac arrest or death.

See Also

• Xanthine
• Caffeine
• Theobromine
• Methylxanthine

7-Methylxanthine Resources
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