8,9-Dehydroestradiol
8,9-Dehydroestradiol is a steroid and estrogen that is closely related to estradiol. It is also known as estra-1,3,5(10),8,9-pentaen-3-ol-17-one and is a minor product of estradiol metabolism.
Chemistry[edit | edit source]
8,9-Dehydroestradiol, also known as estra-1,3,5(10),8,9-pentaen-3-ol-17-one, is a synthetic, steroidal estrogen and a derivative of estradiol. It is specifically a derivative of estradiol with a double bond between the C8 and C9 positions. Other similar estradiol derivatives include 2-methoxyestradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, and 16α-hydroxyestradiol.
Biosynthesis and metabolism[edit | edit source]
8,9-Dehydroestradiol is formed from estradiol in the liver by the enzyme cytochrome P450 1B1 (CYP1B1). It is a minor product of estradiol metabolism, with the major products being 2-hydroxyestradiol and 2-methoxyestradiol. The metabolism of estradiol by CYP1B1 is a part of the endogenous metabolic activation of estradiol, which results in the formation of genotoxic catechol estrogen quinones that can cause DNA damage and mutations.
Pharmacology[edit | edit source]
The pharmacology of 8,9-dehydroestradiol has not been studied in detail. However, it is known to be a potent antioxidant, and it has been suggested that it may have neuroprotective effects. It is also known to bind to the estrogen receptor, but its affinity for this receptor and its estrogenic activity are not known.
See also[edit | edit source]
| 8,9-Dehydroestradiol Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
