8-CAC

8-CAC (also known as 8-Chloro-adenosine-cAMP) is a chemical compound that is a derivative of adenosine. It is a potent and selective P-site inhibitor of adenylate cyclase.

Chemical Structure

8-CAC is a chlorinated derivative of adenosine. It has a molecular formula of C10H12ClN5O6P and a molecular weight of 365.66 g/mol. The chemical structure of 8-CAC includes an adenine base attached to a ribose sugar, which is further attached to a cyclic phosphate group. The 8-position of the adenine base is substituted with a chlorine atom.

Mechanism of Action

8-CAC acts as a potent and selective P-site inhibitor of adenylyl cyclase. Adenylyl cyclase is an enzyme that converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and pyrophosphate. Inhibition of this enzyme leads to a decrease in the levels of cAMP, a second messenger that plays a crucial role in various cellular processes. By inhibiting adenylyl cyclase, 8-CAC can modulate these cAMP-dependent processes.

Applications

8-CAC has been used in various research studies to investigate the role of cAMP-dependent processes in cells. It has been particularly useful in studies investigating the role of cAMP in the regulation of heart function and in the development of heart disease.

Safety

As with all chemical compounds, appropriate safety measures should be taken when handling 8-CAC. It should be handled with care to avoid contact with skin and eyes, and should not be ingested or inhaled.

See Also

• Adenosine
• Adenylyl cyclase
• P-site inhibitor
• cAMP

8-CAC Resources
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