8-CAC

8-CAC (also known as 8-Chloro-adenosine-cAMP) is a chemical compound that is a derivative of adenosine. It is a potent and selective P-site inhibitor of adenylate cyclase.

Chemical Structure[edit | edit source]

8-CAC is a chlorinated derivative of adenosine. It has a molecular formula of C10H12ClN5O6P and a molecular weight of 365.66 g/mol. The chemical structure of 8-CAC includes an adenine base attached to a ribose sugar, which is further attached to a cyclic phosphate group. The 8-position of the adenine base is substituted with a chlorine atom.

Mechanism of Action[edit | edit source]

8-CAC acts as a potent and selective P-site inhibitor of adenylyl cyclase. Adenylyl cyclase is an enzyme that converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and pyrophosphate. Inhibition of this enzyme leads to a decrease in the levels of cAMP, a second messenger that plays a crucial role in various cellular processes. By inhibiting adenylyl cyclase, 8-CAC can modulate these cAMP-dependent processes.

Applications[edit | edit source]

8-CAC has been used in various research studies to investigate the role of cAMP-dependent processes in cells. It has been particularly useful in studies investigating the role of cAMP in the regulation of heart function and in the development of heart disease.

Safety[edit | edit source]

As with all chemical compounds, appropriate safety measures should be taken when handling 8-CAC. It should be handled with care to avoid contact with skin and eyes, and should not be ingested or inhaled.

See Also[edit | edit source]

8-CAC Resources
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