8-Hydroxycarteolol

8-Hydroxycarteolol

8-Hydroxycarteolol is a metabolite of the beta blocker carteolol. It is primarily formed in the liver through the process of oxidation.

Pharmacology

8-Hydroxycarteolol retains the beta blocking activity of its parent compound, carteolol. It is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 receptors. This can lead to a decrease in heart rate and blood pressure, making it useful in the treatment of conditions such as hypertension and angina pectoris.

Metabolism

The metabolism of carteolol to 8-Hydroxycarteolol is primarily mediated by the Cytochrome P450 enzyme system in the liver. This process involves the oxidation of carteolol, resulting in the formation of 8-Hydroxycarteolol.

Clinical significance

Due to its beta blocking activity, 8-Hydroxycarteolol may contribute to the therapeutic effects of carteolol. However, it may also contribute to the side effects associated with beta blockers, such as bradycardia, hypotension, and bronchospasm.

See also

• Carteolol
• Beta blocker
• Cytochrome P450