8-Hydroxycarteolol

8-Hydroxycarteolol is a metabolite of the beta blocker carteolol. It is primarily formed in the liver through the process of oxidation.

Pharmacology[edit | edit source]

8-Hydroxycarteolol retains the beta blocking activity of its parent compound, carteolol. It is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 receptors. This can lead to a decrease in heart rate and blood pressure, making it useful in the treatment of conditions such as hypertension and angina pectoris.

Metabolism[edit | edit source]

The metabolism of carteolol to 8-Hydroxycarteolol is primarily mediated by the Cytochrome P450 enzyme system in the liver. This process involves the oxidation of carteolol, resulting in the formation of 8-Hydroxycarteolol.

Clinical significance[edit | edit source]

Due to its beta blocking activity, 8-Hydroxycarteolol may contribute to the therapeutic effects of carteolol. However, it may also contribute to the side effects associated with beta blockers, such as bradycardia, hypotension, and bronchospasm.

References[edit | edit source]

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