8A-PDHQ
8A-PDHQ is a chemical compound that is used as a pharmacological tool in scientific research. It is a potent and selective antagonist for the adenosine A2A receptor, which is a protein that is encoded by the ADORA2A gene in humans.
Chemistry[edit | edit source]
8A-PDHQ is a quinoline derivative. Quinolines are a class of organic compounds that consist of a benzene ring fused to a pyridine ring. The structure of 8A-PDHQ includes a quinoline core, with additional functional groups that contribute to its biological activity.
Pharmacology[edit | edit source]
The adenosine A2A receptor is a member of the G protein-coupled receptor (GPCR) family, which are proteins that span the cell membrane and transmit signals from outside the cell to inside the cell. Antagonists for the A2A receptor, like 8A-PDHQ, block the action of adenosine, a naturally occurring molecule in the body that has various effects including regulating heart rate and blood flow, and acting as a neurotransmitter in the brain.
Uses in Research[edit | edit source]
8A-PDHQ is used in scientific research to study the role of the adenosine A2A receptor in various physiological processes and diseases. For example, it has been used in studies investigating the role of the A2A receptor in Parkinson's disease, schizophrenia, and drug addiction.
See Also[edit | edit source]
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