A20 cells

A20 cells are a type of cell that are commonly used in biological research. They are a cell line derived from a B cell lymphoma and are often used in studies related to immunology and cancer.

History

The A20 cell line was first established in the 1980s from a mouse B cell lymphoma. The cells were named "A20" after the clone from which they were derived. Since their establishment, A20 cells have been used in a wide range of research studies.

Characteristics

A20 cells are immortalized cells, meaning they can divide indefinitely in culture. They are derived from B cells, a type of white blood cell that plays a key role in the immune system. As such, A20 cells express many of the same proteins and genes as normal B cells, making them a useful model for studying B cell biology.

Use in Research

A20 cells are commonly used in research related to immunology and cancer. They are often used to study the function of B cells and the development of B cell lymphomas. In addition, A20 cells can be used to study the effects of various drugs and treatments on B cells.

Limitations

While A20 cells are a valuable tool in biological research, they do have some limitations. Like all cell lines, they do not perfectly represent the complexity of the human body. Therefore, findings from studies using A20 cells must be validated in other models or in clinical trials.

See Also

• Cell culture
• B cell
• Lymphoma

References

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