ABCC2

ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2), also known as MRP2 (multidrug resistance-associated protein 2), is a protein that in humans is encoded by the ABCC2 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

Function

The ABCC2 protein functions as a Conjugate export pump that plays an important role in the elimination of drugs and toxins from the body. It is located in the cellular membrane of many organs, such as the liver, kidneys, and intestines, where it pumps out substances from the cells into the bile, urine, or intestinal lumen.

Clinical significance

Mutations in the ABCC2 gene are associated with Dubin-Johnson syndrome, a rare condition characterized by chronic, benign, intermittent jaundice. In addition, altered function of this protein has been observed in drug-resistant cancer cells where it is overexpressed.

See also

• ATP-binding cassette transporter
• Multidrug resistance-associated protein
• Dubin-Johnson syndrome

External links

• ABCC2 at the US National Library of Medicine Medical Subject Headings (MeSH)

ABCC2 Resources
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