ABCF2
ABCF2 is a gene that encodes a protein in humans. It is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the MDR/TAP subfamily.
Function[edit | edit source]
The protein encoded by the ABCF2 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. However, this gene is upregulated in a number of cancer cell lines. The gene is located in the mitochondria, which are the energy-producing organelles in cells.
Clinical Significance[edit | edit source]
The ABCF2 gene has been found to be upregulated in several types of cancer, including breast cancer and prostate cancer. This suggests that it may play a role in the development or progression of these cancers. However, more research is needed to understand the exact role of ABCF2 in cancer.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
