ACAT2

From WikiMD's Wellness Encyclopedia

ACAT2 (Acetyl-CoA acetyltransferase 2) is an enzyme that in humans is encoded by the ACAT2 gene. This enzyme is primarily located in the mitochondria, and plays a crucial role in lipid metabolism.

Function[edit | edit source]

ACAT2 is an important enzyme involved in the metabolic pathways of lipid metabolism. It catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. This reaction is a key step in the mevalonate pathway, which is responsible for the biosynthesis of cholesterol, steroids, and other isoprenoids.

Clinical significance[edit | edit source]

Mutations in the ACAT2 gene have been associated with hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. This can lead to the development of atherosclerosis, a disease in which plaque builds up inside the arteries, and can potentially lead to heart disease and stroke.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD