ACOT1

ACOT1 (Acyl-CoA Thioesterase 1) is a protein that in humans is encoded by the ACOT1 gene. This protein is part of the Acyl-CoA thioesterase family, which is a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoA), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoAs.

Function

The ACOT1 protein is an enzyme that plays a crucial role in lipid metabolism. It catalyzes the conversion of acyl-CoA, a key molecule in lipid metabolism, into free fatty acids and coenzyme A. This reaction is important for the regulation of lipid metabolism and the maintenance of energy balance within the cell.

Clinical Significance

Alterations in the ACOT1 gene have been associated with various metabolic disorders, including obesity and type 2 diabetes. Research has shown that overexpression of ACOT1 can lead to increased fatty acid oxidation, which can contribute to the development of these conditions.

See Also

• Acyl-CoA thioesterase
• Lipid metabolism
• Metabolic disorders

References

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