ADAMTS3

ADAMTS3 is an enzyme that in humans is encoded by the ADAMTS3 gene. This gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, which is known for its roles in extracellular matrix organization and disorders. The ADAMTS family members share a common structure, including a propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. These enzymes are implicated in various biological processes, including angiogenesis, coagulation, and wound healing.

The ADAMTS3 enzyme is particularly important in the processing of versican, a large extracellular matrix proteoglycan that influences cell adhesion, proliferation, and migration. Through its action on versican, ADAMTS3 plays a critical role in the development of the cardiovascular system and the formation of blood vessels, a process known as angiogenesis. Mutations in the ADAMTS3 gene have been associated with various pathologies, although the full spectrum of its involvement in disease is still under investigation.

In addition to its role in the extracellular matrix and angiogenesis, ADAMTS3 has been implicated in the regulation of lymphangiogenesis, the formation of lymphatic vessels. This is particularly significant in the context of cancer metastasis, where the lymphatic system can facilitate the spread of tumor cells to distant sites in the body.

Research into ADAMTS3 and its functions continues to uncover its potential implications in health and disease. Understanding the mechanisms by which ADAMTS3 operates not only provides insights into fundamental biological processes but also opens up possibilities for therapeutic interventions in diseases associated with extracellular matrix disorders and abnormal angiogenesis.