ADP-ribosylhydrolase 2
ADP-ribosylhydrolase 2 (ARH2) is an enzyme that in humans is encoded by the ARH2 gene. This enzyme is part of the ADP-ribosylation process, a reversible post-translational modification involved in various cellular functions, including DNA repair, transcription, and cell signaling.
Function[edit | edit source]
ADP-ribosylhydrolase 2 is a member of the Macrodomain proteins family, which are involved in the recognition and hydrolysis of ADP-ribose (ADPr) from modified proteins. ARH2 specifically catalyzes the removal of mono-ADP-ribose from arginine residues in proteins, reversing the modification added by ADP-ribosyltransferase enzymes.
Clinical significance[edit | edit source]
Alterations in the ARH2 gene have been associated with various diseases. For instance, mutations in this gene have been linked to neurodegenerative diseases due to the enzyme's role in DNA repair. Additionally, the overexpression of ARH2 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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