ADX71441
ADX71441
ADX71441 is a selective positive allosteric modulator (PAM) of the GABA_B receptor. It was developed by Addex Therapeutics for the potential treatment of anxiety disorders, pain, and addiction.
Mechanism of Action[edit | edit source]
ADX71441 works by enhancing the activity of the GABA_B receptor, a type of G-protein coupled receptor (GPCR) that is activated by the neurotransmitter gamma-aminobutyric acid (GABA). By modulating this receptor, ADX71441 increases the inhibitory effects of GABA, which can lead to reduced neuronal excitability and potential therapeutic effects in various neurological disorders.
Therapeutic Potential[edit | edit source]
The modulation of the GABA_B receptor by ADX71441 has shown promise in preclinical studies for several conditions:
- Anxiety disorders: By enhancing GABAergic inhibition, ADX71441 may help alleviate symptoms of anxiety.
- Pain management: The compound has potential analgesic properties due to its ability to modulate pain pathways.
- Addiction: ADX71441 may reduce the reinforcing effects of addictive substances, aiding in addiction treatment.
Development and Research[edit | edit source]
Addex Therapeutics has conducted various preclinical studies to evaluate the efficacy and safety of ADX71441. These studies have demonstrated positive results, but further clinical trials are necessary to confirm its therapeutic potential and safety in humans.
Related Compounds[edit | edit source]
Other compounds that act on the GABA_B receptor include:
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
